Turned my head flashes of light kept darting across my eyes. My toes drew up under my feet, and as I moved or I lay on the bed and the calf muscles began to stiffen and Great uneasiness and restlessness, and I felt a desire to walkĪbout and do something rather than sit still and read. Muscles " and a peculiar metallic taste in the mouth. It, towards the evening, I felt a tightness in the "facial Solution (B.P.) with the same quantity of dilute phosphoric acid Three years ago I was reading for an examination,Īnd feeling "run down".
One medical student in 1896 described the experience in a letter to the Lancet: The subject usually dies within 2–3 hours after exposure. Death comes from asphyxiation caused by paralysis of the neural pathways that control breathing, or by exhaustion from the convulsions. These are followed by postictal depression. Convulsions lead to lactic acidosis, hyperthermia and rhabdomyolysis. The convulsions progress, increasing in intensity and frequency until the backbone arches continually. The spasms then spread to every muscle in the body, with nearly continuous convulsions, and get worse at the slightest stimulus.
Ten to twenty minutes after exposure, the body's muscles begin to spasm, starting with the head and neck in the form of trismus and risus sardonicus. Similarly, the median lethal dose for dogs, cats, and rats ranges from 0.5 to 2.35 mg/kg.
The probable lethal oral dose in humans is 1.5 to 2 mg/kg. For this reason, strychnine poisoning is often portrayed in literature and film, such as the murder mysteries written by Agatha Christie. It produces some of the most dramatic and painful symptoms of any known toxic reaction, making it quite noticeable and a common choice for assassinations and poison attacks. Strychnine poisoning can be fatal to humans and other animals and can occur by inhalation, swallowing or absorption through eyes or mouth. Lactic acidosis, Hyperthermia, Rhabdomyolysis
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